Synthesis of 35-40 mers of RNA oligomers from unblocked monomers. A simple approach to the RNA world.
نویسندگان
چکیده
RNA oligomers greater than 35-40 mers in length form in one day in the montmorillonite clay-catalyzed reaction of unblocked RNA monomers at 25 degrees C in aqueous solution.
منابع مشابه
Catalysis in prebiotic chemistry: application to the synthesis of RNA oligomers
The role of catalysis in prebiotic synthesis is illustrated using the montmorillonite clay catalyzed synthesis of RNA oligomers. Reaction of activated monomers of nucleotides in pH 8 aqueous solution containing Mg2þ in the presence of montmorillonite yields 6–14 mers. The reaction takes place at the clay interlayer. The catalyst controls the synthesis of RNA oligomers in that a limited number o...
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5'-Nucleotides of A and U with the phosphate activated with 1-methyladenine generate RNA oligomers containing 40-50 monomers in 1 day in reactions catalyzed by montmorillonite. The corresponding monomers of C give oligomers that are 20-25-mers in length after a 9-day reaction. It was not possible to determine the chain lengths of the oligomers of G since they did not give well-defined bands on ...
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عنوان ژورنال:
- Chemical communications
دوره 12 شماره
صفحات -
تاریخ انتشار 2003